Pharmacokinetic factors influencing risk assessment: saturation of biochemical processes and cofactor depletion.
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic factors influencing risk assessment: saturation of biochemical processes and cofactor depletion.
Models generally consider risk to be a function of the hazard (toxicity) and exposure (dose). That function is best described by the dose response of the toxic effect. For any risk assessment system to be effective, it should consider that dose-response relationship. Saturation phenomena often produce nonlinear dose curves, and any risk assessment system should be able to address such effects. ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1994
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.94102s1113